Xenopus laevis: the frog prince among model organisms

2010-05-17 majifen 872

In addition, although the African clawed toad is regarded as a prince, its food appearance is really not flattering. Interestingly, in the prince's hometown - Africa, it also has the habit of "aestivation". When the pond dries up in summer, the African clawed toad will dig a hole in the mud and hide in it, remaining dormant until the rainy season. From 1927 to 1930, Professor Hogben worked at the University of Cape Town in South Africa and tried to conduct his experiments with the local Xenopus laevis. In addition, Xenopus laevis is very aggressive and easy to raise. Since the 1950s, Xenopus laevis has gradually become a model animal for developmental biology research. This series of work was also conducted using Xenopus laevis as a model. Since then, oocyte expression systems have played an important role in cell biology research. It was not until 1988 that MPF was purified and found to consist of two proteins, one is cyclin (a protein that is periodically expressed during cell division) and the other is a cyclin-dependent protein kinase. Experimental methods established in Xenopus laevis can be directly applied to Xenopus tropicalis.

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